�In patients with diabetes, the CYPHER� Sirolimus-eluting Coronary Stent outperformed the Taxus� Stent with significantly frown rates of in-segment restenosis (a reblockage within the stented surface area), target lesion revascularization (TLR; the need for another interventional procedure) and major adverse events (MACE, a composite of death, heart attack and TLR) at nine months according to clinical data appearing lately in the Journal of the American College of Cardiology.
In this multi-center randomized clinical test, the sextet month charge per unit of in-segment restenosis was more than five times lower for the CYPHER� Stent compared to the Taxus� Stent (4.0 percent vs. 20.8 percent respectively (p
"These information provide interventional cardiologists with valuable modern information just about the utilisation of drug-eluting stents in patients with diabetes, whose coronary arteria disease presents such therapeutical challenges," aforesaid Seong-Wook Park, M.D., PhD, F.A.C.C., and Principal Investigator of this trial. Dr. Park is from the Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Cordis has no financial relationship with Dr. Park.
"The pregnant reduction in restenosis associated with the CYPHER� Stent, which translated to better outcomes for patients in terms of TLR and overall MACE, is impressive. It as well is encouraging to line the data in this study on the safety of the CYPHER� Stent in this difficult-to-treat patient role population," Dr. Park continued.
There was no difference between the deuce drug-eluting stents in the rates of death or myocardial infarction (heart attack). The charge per unit of last was 0 percent for the CYPHER� Stent vs. 0.5 percent for the Taxus� Stent (p=0.999). The incidence of heart attack between the two groups was 0.5 pct (p=0.999).
The study included a total of 400 patients divided equally between the CYPHER� Stent and the Taxus� Stent (200 each) from five-spot academic medical centers in Korea between May 2005 and March 2006. All patients had clinically outlined diabetes. This study was supported by the Cardiovascular Research Foundation (Korea) and a assignment from the Korean Ministry of Health and Welfare.
"This study adds to the growing physical structure of clinical evidence around the CYPHER� Stent in diabetics with coronary arteria disease," said Campbell Rogers, M.D., Chief Technology Officer, Cordis Corporation. "These information are coherent with other recently reported clinical visitation data that clearly indicate that the CYPHER� Stent performs other than than the Taxus� Stent in diabetics, which has been a topic of discussion and debate within the medical community for some time."
The CYPHER� Stent does not have an approved indication for role in patients with diabetes in the United States.
About the CYPHER� Stent
The CYPHER� Stent has been chosen by cardiologists worldwide to treat or so three gazillion patients with coronary arteria disease. The safety and efficacy of the device is supported by a robust clinical trial programme that includes more than 70 studies that examine the operation of the CYPHER� Stent in a broad mountain chain of patients.
For more finish information on indications, contraindications, warnings and precautions, see the Instructions for Use available at http://www.cypherstent.com.
About Cordis Corporation
Cordis Corporation, a Johnson & Johnson company, is a ecumenical leader in the development and manufacture of interventional vascular technology. Through the company's invention, research and development, Cordis partners with interventional cardiologists worldwide to treat millions of patients who brook from vascular disease. More information virtually Cordis Corporation can be found at http://www.cordis.com.
Cordis Corporation has entered into an exclusive world-wide license with Wyeth for the localised delivery of sirolimus in certain w. C. Fields of utilization, including delivery via vascular stenting. Sirolimus, the
